Spurs, who have blown a two-goal lead for the second time this season after losing 3-2 at Brighton, were 2-0 up after just 11 minutes through Dominic Solanke and Dejan Kulusevski as Chelsea defender Marc Cucurella was forced into a change of boots after slipping for both goals.
Jadon Sancho then got the visitors back into the game in the 17th minute as he produced a wonderful curling low finish off the post from outside the box.
Chelsea midfielder Moises Caicedo then won a second-half penalty as he drew a rash challenge from Yves Bissouma that allowed Palmer to equalise from the spot in the 61st minute.
Chelsea always looked likeliest to win the game and Enzo Fernandez completed the turnaround in the 73rd minute with a powerful near-post volley.
Spurs’ defensive frailties were on display again as Sarr gave away another poor penalty that allowed Palmer to produce a cool Panenka in the 84th minute to extend their lead.
Heung-Min Son pulled a stoppage-time goal back but it was too little too late as Chelsea held on for a fourth straight league win to move second behind Liverpool, who have a game in hand after the Reds’ match against Everton was postponed on Saturday.
Spurs, meanwhile, are heading in the opposite direction with back-to-back league defeats leaving them 11th, seven points off the top four and boss Ange Postecoglou under even more pressure.
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